CryoSPARC is an advanced software platform designed for cryo-electron microscopy (cryo-EM), playing a crucial role in research and drug discovery processes.

This document provides the user manual for CryoSPARC, which has been installed on DARWIN.

CryoSPARC will be run in a screen mode at one of GPU node ( r1t00 with tesla_t4:1 in this example ). You need to remember which login node you are.

[(workgroup:user)@login01 ~]$ screen
[(workgroup:user)@login01 ~]$ salloc -p idle --gpus=tesla_t4:1 -N1 -n1 --cpus-per-task=4 --mem=200G --time=01:00:00
[(workgroup:user)@r1t00 ~]$ export CRYOSPARC_INSTANCE_DIR=$TMPDIR
[(workgroup:user)@r1t00 ~]$ vpkg_require cryosparc/4.3.1
[(workgroup:user)@r1t00 ~]$ cryosparcm start  # this start cryosparc_master and set up environment.

You will see below if cryoSPARC runs successfully. Please remember your username, password, and port name, as they are printed out.